Sentence examples for based on binding pocket from inspiring English sources

In order to compare our results, we relate our results to previous work based on binding pocket similarity in the following section.

The oligopeptide products of NRPS gene clusters may be predicted in silico based on binding pocket analyses of A-domains [ 12, 13], phylogeny and the co-linearity rule, i.e. the order of A-domains is co-linear with the amino acid sequence of the finished peptide [ 14].

Several methods based on binding pockets comparison have been proposed (Hoffmann et al., 2010; Morris et al., 2005; Najmanovich et al., 2008), but they require the knowledge of protein 3D structures, which is not genome-wide available.

31 The pharmacophore model was refined further based on the binding pocket of the dopamine D1 receptor (drd1) structure model.

Our structural and functional results also shed light on strategies to restore an efficient hSTING response to DMXAA based on the binding-pocket S162A and Q266I substitutions.

AHO and amino acid substrate assignments for A domains are shown in Table 2 and Fig. 4. A domains of all terminal modules were predicted to code for AHO based on a larger binding pocket size which, in most cases, includes one or two negatively charged residues or a few polar residues (Table 2, Fig. 7E, compare with Fig. 7D).

These results indicated that stronger PI3K inhibition by FK-A11 is based on stronger binding to the ATP-binding pocket of PI3K.

Binding sites of these models were selected based on the ligand-binding pocket of the template.

Assuming that the inhibitor binding modes are similar in the target and the template protein structure, active sites of the molecules were delineated based on the ligand-binding pocket of the template protein.

Based on the binding conformations and their alignment inside the binding pocket of CCR5, three-dimensional structure activity relationship (3D QSAR) analyses were performed on these antagonists using comparative molecular field analysis (CoMFA) and comparative molecular similarity analysis (CoMSIA) methods.

Call, raise or fold based on your pocket cards.