Sentence examples for based on binding mode from inspiring English sources

In the past decade, several methods based on binding mode contact analysis have been developed for the characterization of protein ligand interactions in docking experiments.

The design is based on binding modes between the two protein families.

The scoring function further ranks these modes based on binding energy evaluations.

The mode of action of Lat B is based on binding to actin monomers, thus preventing their polymerization [ 19].

Based on this binding mode of Cblin to the TKB domain, we can design drugs against unloading-mediated muscle atrophy.

From this, we propose a classification of PPI stabilizers based on their binding mode and the architecture of the complex to facilitate the structure-based design of stabilizers.

Based on the binding mode, N-ethylmethylamine was identified as a promising scaffold that forms hydrogen bonds with the catalytic residues of sEH, Asp335, Tyr383, and Tyr466.

In contrast to the original design hypothesis based on the binding mode of tolrestat (1), both inhibitors leave the specificity pocket in the closed state.

Based on the binding mode, predictive 3D-QSAR models were established, which had conventional r2 and cross-validated coefficient values (r2cv) up to 0.982 and 0.601 for CoMFA and 0.954 and 0.598 for CoMSIA, respectively.

This work has utilised a structure-based lead generation approach consisting of homology modelling of the target protein, construction of a library of compounds, followed by modification of hits obtained based on predicted binding mode.

Based on the binding mode of sialyl Lewis X, the two acidic groups of the malonate are designed to form ionic interactions with two important lysines in the active site of P-selectin, Lys113 and Lys111.