Sentence examples for based on binding matrix from inspiring English sources
The most recent method is based on binding matrix technique, in which the information concerning both the miRNA sequence and a set of experimentally validated targets is used to perform predictions [ 23].
They constructed a set of five position frequency matrices based on binding sites for MEF2, Myf, SRF, TEF-1 and Sp1 transcription factors which were found to bind within these sequences.
Bind plasmid DNA to a diatomaceous earth based DNA binding matrix by addition of 20 ml re-suspended matrix to cleared lysate.
We next assessed whether NFI in vivo binding sites specificity correlates with binding site predictions based on a weight matrix model determined from in vitro binding assays using various analytical strategies.
For each regulatory interaction, binding scores were calculated based on position matrix values or inserted from the original sources.
Based on the binary matrix, similarity matrixes were calculated using Jaccard's and Dice's coefficients [ 23, 24].
The idea of employing carbohydrate materials as modification of HILIC was based on hydrophilic binding principle of carbohydrate matrices such as cellulose and sepharose to oligosaccharides [ 31].
However, since this prediction matrix is based on NFI binding specificity in vitro, the specificity of this family of proteins may be different from that observed in the cell, where interactions with other transcription factors may take place and DNA accessibility may be restrained by chromatin.
However, previous studies identified the protein Scyl1 binding partner 1 (Scyl1basedbased on its binding to Scyl1 [30].
Analytical standard errors are not given in the last column because several of the inequality constraints are binding, rendering inference based on the information matrix unreliable These results demonstrate that the point estimates from the standard bivariate ACE model are sensitive to assumptions about the spousal cross-trait genetic correlation.
