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Here, we used an original approach that consists in building a Hidden Markov Model (HMM) profile based on available structures and structurally well-annotated sequences and then in enriching it using an iterative procedure.
A simple model of ADAMTS-5 TIMP-3 wADAMTS-5 TIMP-3based on available structures using Pymol.
Based on available structures of members of the GS fold these TM helices are predicted to stick out of the core fold without distorting it and are likely to anchor these Pup ligases to the cytoplasmic face of the cell membrane.
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Structures of the remaining 11 yBRDs were modeled based on available BRD structures.
Most of these crosslinking approaches are based on available atomic structures for chemoreceptor homodimers, the fundamental building block for higher‐order networks.
The pharmacophores are elucidated based on available crystal structures of bound ligands and/or simple examination of the binding site, and are used to filter the saved poses output from the docking program, and remove any that are incompatible with the model.
Mg1 would interact with the β- and γ-phosphates of ATP and Mg2 would interact with the γ-phosphate based on available MurC structures.
Selection of the spacer is based on available crystal structures or trial and error.
Based on available crystal structures and biochemical information, significant new insights have emerged into modes of receptor control, its deregulation in cancer, and the nuances that differentiate the four human receptors.
Based on available crystal structures and biochemical data, the transport of substrates by AcrB has been proposed to take place via a functional rotation, in which each monomer neatly assumes in a succession of steps each of three particular conformations [ 9, 14, 33], labeled as L (loose), T (tight), and O (open) according to Seeger et al. [ 9].
The algorithm is based on available Vandermonde structure [26] and Kronecker product structure in the matrix blocks, also uses the polarization-sensitive array processing technology [27].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com