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For this study, we selected ten tumor versus normal CpG methylation studies profiled on the Illumina HumanMethylation27 BeadChip, four studies from Gene Expression Obmibus (GEO) and six studies from The Cancer Genome Atlas (TCGA) database based on available sample size (N > 40) and the availability of normal adjacent methylation profiling status (at least three normal samples).
The toolbox uses one of the four well-known methods to estimate distribution parameters based on available sample data: maximum likelihood estimates; least squares estimates; method of moments; and method of L-moments.
Based on available sample size, exact confidence limits for binomial proportions estimate the frequency of mutations investigated in the present study as ranging from 0% to 8% in individuals with probable CAA in the general population.
[15] Novel variants and/or duplication of the APP locus in sequenced patients were used to infer the probability of identical findings in the general population of sporadic CAA patients by computing exact confidence limits for binomial proportions based on available sample size [18].
Bootstrap is a re-sampling method for studying the variation of an estimated quantity based on available sample data [ 21].
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The analyses that estimated the odds ratios for association between cancer grade, by stage, and the Gleason score, and median levels of CAUCd (<= 1.12 vs. > 1.12 μg/g creatinine) and BCd (<= 0.87 vs. > 0.87 μg/L) were based on available samples from cases.
Heckman's method is based on available pre-sample information with which the conditional distribution of the initial values can be approximated via a reduced form.
Based on available techniques, samples should be taken at pharmacokinetic steady state, which would usually be after about four doses (assuming 12-hourly dosing) [ 97].
Annual exposure rate estimates by plant, department, and job were developed by Rinsky et al. (2002 , 1987 based on available air sampling data.
Based on available data, 18,164 water samples from cooling towers and 1,277 water samples from water fountains were tested at the Food and Water Microbiology Laboratory, SGH, during 2000 2008.
We suggest a testing algorithm to identify genomic variation in clinical samples based on available technologies for mutation detection and the clinical presentation of the patient.
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