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They represent a subset of genes where silencing may play a role in the development of high grade prostate cancers based on our array results, but also based on available functional information from current literature.
In summary, based on available functional information, these genes unique to YHJ7 might directly or indirectly facilitate the adaptation of YHJ7 to the industrial wine fermentation environments.
This system provided unbiased genome-wide coverage with sufficient depth to reliably capture the most well characterized mechanism of resistance in all cell lines processed and generate many believable additional hits based on available functional annotation.
Based on available functional and molecular evidence, including the findings presented in this study, adult NSC seem to have far more in common with developmental radial glial NSC than they do with mature astrocytes.
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Based on available structural and functional data of the activation process in class-A GPCRs, we propose here that a change in protonation status, together with proton transfer via conserved structural elements located in the transmembrane region, are the key elements essential for signal transduction across the membrane.
We developed Prosecutor, an application that enables researchers to rapidly infer gene function based on available gene expression data and functional annotations.
This chapter describes how to design a compliant functional study based on available standards, illustrated through examples dealing with the functional evaluation of soft tissue implants.
Based on available information, we have developed a functional event diagram of the process.
Functional analysis based on available gene annotation indicates that most conserved genes (levels 1 and 2) are responsible for basic cellular processes (e.g., DNA replication, transcription, translation, etc), while most genus- and species-specific genes (levels 5 and 6) are hypothetical proteins of unknown function (see Additional files 2 and 3).
The main focus of the current study was to include known functional polymorphisms candidate genes based on available literature.
In this study, we represented genes as nodes of a graph whose edges reflect functional relatedness among the genes, based on available information regarding genes.
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