Our study, based on assessments at the 8 km2-level, revealed that endemics of major indicator taxa show a steady decline in richness with increasing forest conversion, i.e. from near-primary forest to annual crops.
All analyses of the WE-CARE validation were based on assessments at Week 0, except for test-retest reliability, which incorporated assessments at Week 0 and Week 2. Initial factor analyses for item reduction were conducted with the aim of establishing which of the provisional 68 items in WE-CARE belonged to domains or conceptual areas and which items should be retained.
The dose-escalation protocol, based on assessment of toxicity at 12 weeks, was as follows.
Our study was based on assessment of the variables at a single time point only and we did not follow our patients to assess the incidence of thrombotic events.
For patients who discontinued between years 1 and 2, radiographs were obtained at an early termination visit; in these patients, the 2-year data were imputed using linear extrapolation based on assessments performed at baseline and at the time of discontinuation.
If patients sustained clinical decline without radiographic progression, based on assessment from the treating practitioner at our institution, patients were removed from trial.
The calculation of QALYs was planned to be based on assessment of health related quality of life at six months from randomisation.
The indirect costs will be based on assessment of days with loss of productivity at work due to health problems and productivity loss due to sickness absence, using the Dutch productivity and disease questionnaire (PRODISQ) [ 38].
Whereas previous results are primarily based on assessments of patient health at either an unknown or known time following a cardiovascular event, the current acute health states represent a year that includes the event.
The research was based on an assessment at one time point, in the second-half of pregnancy, and the details are described elsewhere (Rochat et al. 2011).
