Sentence examples for based on antigen target from inspiring English sources
The carboxyl group of GO sheets can be activated using EDC/NHS reaction and preparation of the GO based on antigen target for GO-BSA.
DiscoTope [ 10] predicted antigenic determinants based on antigen 3D structures.
Many of the ADCs that are in clinical development are based on antigens that had previously been tested as targets for traditional unarmed antibody therapeutics.
The tumor specificity of some αβ TCRs is becoming apparent based on antigens that have already been described, such as the cellular stress indicator MHC Class I chain-related A (MICA), which is targeted by Vγ1Vδ1 TCR [132].
In contrast to bioengineering strategies, immunological approaches are based on targeting antigen delivery to M cells for specific uptake; direct targeting should provide greater control over the induced immune response than unregulated transport to draining lymph nodes.
Biochemical affinity-based approaches, based on highly specific antigen targets, can yield high efficiency separations but are inherently limited by the interference of the labeling moieties, i.e., the receptor ligand binding itself can perturb the cell.
We describe a strategy for specific immunotherapy of autoimmune disease based on targeting the antigen-specific T cells in an experimental model of myasthenia gravis.
Based on expression of target antigens and binding of BNP associated alloantibodies of tissues differentially affected in BNP, we conclude that MHC I-specific BNP alloantibodies mediate the pathogenicity of BNP in the calf and that cells with high MHC I expression were preferentially affected in BNP.
After affinity purification, the antigens were separately coated as lines onto nitrocellulose membrane chips that were fixed onto a plastic strip, creating a line immunoassay format based on the main target antigens of anti-PM/Scl antibodies.
These rules were based on: the target residue belonging to a topological neighbourhood of the antigen in the structure of the complex between antibody and antigen; its absence of functional importance for the interaction with the antigen; and its solvent accessibility in the structure of the free antibody.
