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Potential coverage can be assessed by evaluating vaccine-induced immune sera in serum bactericidal antibody assays using human complement (hSBA) against diverse MnB isolates selected based on antigen diversity.
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DiscoTope [ 10] predicted antigenic determinants based on antigen 3D structures.
Yao et al. tested predictions based on antigen protein structures.
Immunotherapeutic approaches are being developed based on antigen-specific T lymphocytes, such as antigen vaccination or adoptive T-cell transfer.
It is interesting that natural populations in China have relatively high genetic diversity based on the nucleotide diversity and haplotype diversity (Table 1).
The most extensive accepted classification of Salmonella strains is based on the diversity of two differentially expressed H flagellar antigens: flagellin phase I and phase II antigens (codified by fliC and fljB genes), and the O antigens of the bacterial lipopolysaccharide, both determined by serotyping [ 7].
Diversity measures based on polymorphic antigen encoding genes, barcoding, microsatellite loci and genome-wide single nucleotide polymorphisms [5], [8], [9] define the number of distinct alleles and/or genomes per infected human, the latter termed multiplicity of infection (MOI).
There is some variation in the observed diversity patterns based on the different diversity measures applied.
The allelic diversity was based on Nei's diversity [51], which is the calculation 1-Σ (allele frequency)2.
Next, we calculated a similar score based on gender diversity.
I'm so inspired for my new collection, which is based on cultural diversity and unity.
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