Typically, cell line-based assays are preferred to those based on animal models, reflecting the low cost, high reproducibility and bioethical rationale for these assays.
Investigation of percutaneous helminth infection is generally based on animal models or excised skin.
Assessments of new DES are based on animal models or in vitro release systems, which have several limitations.
Many recent reports have described the effects of the consumption of milk containing rhLF and rhLZ (recombination human lysozyme) on both human health (based on animal models) and as treatments in animal models of disease17, 32,33,34.
They primarily address temporal lobe epilepsy (TLE), because the data have either been based on animal models of TLE or patients with intractable TLE.
Immunological knowledge on processed biological implants and mesh-prostheses is still mainly based on animal models, lacking information on the species-specific human immune response.
Here we report an inventory of common designs sampled from anti-inflammatory, respiratory and metabolic disease drug discovery studies, all of which are based on animal models of disease involving pharmacological and/or patho/physiological interaction challenges.
However, the measurements are indirect, based on animal models, and require extrapolation to human exposure conditions.
"My former advisor at Oxford has a variety of interests, all very much based on animal models of how the brain is organized for skilled performance.
However, experimental animal models do not fully elucidated the clinical conditions they aim to mimic, and both scientists and physicians have raised several criticisms on the relevance of pre-clinical experimental research based on animal models and its translation to human pathology.
