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Data presented based on an imputed sample of 4799.
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We computed likelihood ratio tests comparing the significance of nested models using models based on one imputed value.
We will examine the structure and pattern of missing data and, if appropriate, will present a sensitivity analysis based on data imputed using a multiple imputation model.
It has been shown that the efficiency of an estimate based on m imputed data sets is approximately (1 + γ/ m)−1, where γ is the rate of missing information for the quantity being estimated (Little and Rubin 2002).
This paper presents a proposal based on an evolutionary algorithm to impute missing observations in multivariate data.
In Table 3, we present the standard risk prediction model without estradiol and an enhanced model with imputed estradiol based on an average of five imputations.
This conclusion was based on both imputed data with a high confidence score for Val103Ile (posterior probability >0.99 using IMPUTE) and on directly genotyped data for both polymorphisms on a subsample of the study group (Val103Ile, n = 5,516 and Ile251Leu: n = 5,039) [1].
When the weights are based on the imputed pre-treatment cholesterol there is a clear protective association of statin use on CHD consistent with previous RCTs.
GWAS based on the imputed data gave rise to similar results, but showed an even higher number of SNPs underlying the MCR1 associated signal.
Genotypes for animals of the validation population were imputed based on an increasing number of highly informative reference animals with high-density genotypes.
Although imputation did not change our primary conclusions, results based on the imputed data should be interpreted with caution.
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