Sentence examples for based on an attenuated from inspiring English sources
Another Ebola vaccine, based on an attenuated vesicular stomatitis virus has shown efficacy in post-exposure treatment of nonhuman primates to Ebola infection.
This conclusion was further corroborated by additional experiments based on an attenuated Poissonian light with a mean photon number of one.
A: Even though this vaccine is based on an attenuated virus, it is replicating at least some in humans.
VA7 is a neurotropic alphavirus vector based on an attenuated strain of Semliki Forest virus.
In this study we analyzed the functionality of a new live C-Raf vaccine based on an attenuated Salmonella enterica serovar Typhimurium aroA strain in two Raf dependent lung tumor mouse models.
In previous studies, oncolytic alphavirus VA7, which is based on an attenuated A7 74) strain of Semliki Forest virus (SFV), was capable of eradicating human brain tumors and melanoma xenografts in immunocompromised mice following just a single intravenous injection [ 9, 10], while in other occasions intratumoral administration route was proven superior [ 11– 13].
The restricted use of traditional VACV smallpox vaccines due to safety concerns, particularly for people with impaired immune systems [5] has led to the development of potentially safer alternative vaccines based on a highly attenuated, non-replicating poxvirus, Modified Vaccinia Ankara (MVA; reviewed in [6], [7].
In 2009, Sanaria submitted an Investigational New Drug application to the Food and Drug Administration for their PfSPZ vaccine candidate based on a non-replicating, attenuated sporozoite stage parasites administered through the intradermal or subcutaneous route.
A similar approach is being developed based on the attenuated DENV-2 virus, DENV-2 PDK-53, and three chimaeric viruses containing the prM and E genes of DENV-1, DENV-3, and DENV-4 virus in the genetic backbone of the DENV-2 PDK-53 virus (termed DENVax).
Nucleic acid vaccines have the potential to address issues of safety and effectiveness sometimes associated with vaccines based on live attenuated viruses and recombinant viral vectors.
