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The TLow is thus personalized based on alterations in lung mechanics, identified by changes in the slope of the expiratory flow curve (Fig. 2b).
Such individual differences in stress vulnerability are based on alterations in neural circuits/mechanisms designed to properly tune and terminate stress responses.
Multiscale modeling has been used to examine the circuit level in order to evaluate how the level of pain perception may be modulated based on alterations in network dynamics [79].
Although mechanisms of alcoholism remain to be elucidated, the molecular hypothesis postulates that that alcohol dependence and toxicity result from neuroadaptations to chronic alcohol consumption based on alterations in gene expression.
Classification of these disorders is usually based on alterations in function or structure [ 13].
This methodology has been previously utilised to predict perioperative infectious complications based on alterations in T cell pathways [ 10].
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Several genetically modified strains have been used for over production of shikimic acid by fermentation, based on alteration in the central carbon metabolism [10] [15].
Annexin V binding assay detects apoptotic cells significantly even earlier than detections based on alteration in gross DNA structures [ 31].
Gene interaction was then assessed quantitatively by growth curves for approximately 5,000 double mutants, based on alteration in the dose response to growth inhibition by oligomycin, a toxin extruded from the cell at the plasma membrane by Yor1.
Generally, it is believed that the beneficial effect of training on systolic- and diastolic function is based on alterations of the Ca2+ regulatory systems involved in the excitation-contraction coupling and relaxation processes [ 33].
While this study itself does not attempt to look at the early diagnostic capabilities of PBMCs, the results obtained from the work are a necessary first step towards a multiplexed assay based on alteration of gene expression in PC for potential application in high-risk groups [28].
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