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Only Gøtzsche and Nielsen provided data on the increased relative risk of surgery with screening, with two estimates: 31% based on the better quality trials and 35% based on all trials reporting this outcome.
Based on all trials, in which subjects showed a response towards the playback stimuli, we calculated an Orientation Index (OI) for each stimulus and subject, according to the formula OI = (number right head turns – number left head turns)/(number right head turns + number left head turns).
Analysis of fMRI data was based on all trials.
Nevertheless, the observed results are consistent with those based on all trials and may be due to lack of statistical power.
Here, the absolute AUC value was even higher than the AUC based on all trials, indicating at least equal sensitivity and specificity using this specific trial window.
RT was computed for each condition (low short, low long, high short, and high long), based on all trials with an RT of > 700 ms per condition, including those coded as artefactual in the EEG analysis.
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Based on all these considerations, several clinical trials aiming to improve the first-line treatment of patients with chronic phase CML have been performed or are at present ongoing.
For each trial, the normalized wind speed estimate was defined as the wind speed estimate for each separate trial (per participant), divided by the average estimate based on all 144 trials per participant.
The conclusion for tumour response is similar to that reported by A'Hern et al, 1988 whose analysis was based on all chemotherapy trials published by 1986.
The summary estimate for the risk difference, 0.27% (95% confidence interval −0.10 to 0.63; P=0.15), based on all 22 trials, was neither clinically nor statistically significant.
An initial Cox proportional hazards model based on all five trials (797 patients, 20/797 cases dropped) was generated with time to healing (days) as the dependent variable, healing as the event, study centres as strata, and bandage type as the only covariate.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com