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Also shown are pooled estimates of the risk of uveal melanoma based on all studies for individual variants and one, two or more and any MC1R variant.
This was performed by generating an mRR based on all studies, followed by the removal of one study at a time to compare the overall mRR with mRRs from models with one study removed.
The resulting synthesis was based on all studies included in the analysis.
Meta-analysis Based on all studies, including 48,808 cases of type 2 diabetes, the pooled OR was 1.24 (95% CI 1.09 1.40).
The shape of the ERC based on the cohort studies only was similar to the shape of the ERC based on all studies.
The network diagrams, based on all studies included in the NMA, are presented in Figures 33 (efficacy outcomes) and 4 (safety outcomes).
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Minor allele frequencies were calculated based on all study participants.
For RCTs in which different doses of biologic DMARDs were administered, efficacy estimates based on all study arms were included.
The model analysis estimated OLAI to be a less costly and more effective strategy than RLAI based on all studied base-case parameters.
But the reported results are based on all study subjects where there is no association of smoking with DE exposure; therefore smoking is not a confounder.
Risks were also increased with increasing peak intensity with follow-up to 1981 (ptrend = 0.00987 based on exposed subjects only and pttend = 0.0485 based on all study subjects), but not with follow-up from 1981-1994 or 1995-2004.
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