An example of a MAGE data type creation and data usage is shown in Additional file 1. Users can compose queries based on all the previously defined metadata fields through the graphical query form.
Irestedt et al. [ 3] concluded, based on all of the previously used loci, but with a glyceraldehyde-3-phosphodehydrogenase (GAPDH) intron instead of ß-fibrinogen, that Hemitesia was also part of this clade.
Based on all of these previously published hypotheses, we think that a multifactorial aetiology is the best match with regard to BEN pathophysiology, with a genetic predisposition being the 'condicio sine qua non' for the development of BEN.
Data on 1,000 genomes [ 23] for Caucasian (CEU) and Han Chinese (CHB), as the most closely related and available population to the NZ Māori and Pacific populations, was used to define haplotype blocks based on all the SNPs previously associated with SU in GWAS studies within the 1.3-Mb region of chromosome 11 (Additional file 2: Figure S1).
To be clear, the app doesn't just spit back one decision, but rather displays your list of options and your overall feeling about each, based on all the influences you previously provided.
The genetic risk score was calculated based on all 26 SNPs using a previously reported weighting method [ 14].
The topology of the consensus tree produced by our phylogenetic analyses is very similar to the trees obtained previously based on all protein-coding genes of the mitochondrial genomes [ 6, 7]: pulmonates are paraphyletic, at the base of euthyneurans (opisthobranchs and pulmonates); opisthobranchs (including Siphonaria) are monophyletic, at the tip of the tree.
