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The generality of these observations is reflected in a cumulative human-mouse conservation profile based on all known mouse miRNAs that can be aligned to the human genome (Figure 2B).
Significance of gene ontology (GO) terms among our significant genes was determined in two complementary ways: a binomial sampling test, and a permutation test (GO terms are a controlled vocabulary which classifies genes based on all known functional associations determined computationally or experimentally).
The simplicity of this technique is its most important advantage based on all known reservations today [ 68].
For example, the first model was based on all known plasmid-mediated qnr sequences excluding the sequences from the class qnrA.
Next, to discover and visualize the biological connectivity of the estrogen-responsive genes, the IPA network generating algorithm is used to maximize the interconnectedness of the genes based on all known connectivity in the database.
To assess this hypothesis, we built an evaluation set based on all known binary protein interactions in E. coli that have 3D structures of the complex as recently summarized (Rajagopala et al., 2014).
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Rather than considering the neuroanatomical data alone, Mayer would like to see a family tree based on all the known data before deciding.
To determine whether neuroendocrine differentiation itself has prognostic significance, we pooled the NEC and IMC-NOS cases together and performed multivariate analyses based on all the known prognostic factors in addition to neuroendocrine differentiation.
IPA predicts functional networks based on known protein protein and functional interactions.
IPA software predicts functional networks based on known protein-protein and functional interactions.
STRING identifies and visualizes functional networks based on known and predicted protein-protein interactions [ 24].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com