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20 ul of 1.5 uM ATP (Sigma, #A1852) in PBS is plated in 384-well white assay plates (Aurora, 00030721) and was exposed to the 1584 cherry-picked compounds chosen based on activity of the platelet dense granule release primary screen (AID1663) and structure to compounds with the highest activity, to provide some SAR data.
A novel method is developed for selective electrochemical detection of guanine (GA) based on activity of gold mercaptopropionic acid self-assembled monolayers (Au-MPA SAMs) functionalized via covalent binding of 5-amino-1,10-phenanthroline-Fe(II) complex (5Aphen-Fe(II)).
In the present study, we have evaluated MY-24 in two small animal models of acute arenaviral infection based on activity of the compound in cell culture.
For example, chloramphenicol-resistant strains in which resistance is exclusively based on activity of chloramphenicol acetyltransferases do not show resistance to florfenicol (35 ).
However, all these methods require some other, efficient mechanism of cellular entry, either nonspecific or based on activity of a specific molecular marker triggering cellular entry.
This work confirmed and extended the previous finding, based on activity of hexapeptide analogues, that residues 7 10 contain key elements necessary for its biological activity of somatostatin [ 13].
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16 Related concepts include active life expectancy based on activities of daily living, disability-free life expectancy based on disability measures, dementia-free life expectancy, and others.
5 28 29 30 If more than one functional outcome was reported we used measures based on activities of daily living score.
There have been calls for Justice Clarence Thomas to step aside, based on activities of his wife, Virginia, in groups opposed to the law.
Economic historians of the Mediterranean developed a "reputation model" based on activities of Maghrebi Jewish traders recorded in the Genizah, and recent books by scholars including Marina Rustow, Arnold Franklin, and Jessica Goldberg have probed the Genizah to write on relationships between Jews, Karaite Jews, and Muslims in the region.
Interactions in the model are based on activities of individual phospho-epitopes and binding sites of proteins involved in G2/M.
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