Another approach to obtain good results without a large-scale facility is to develop a customized system based on a X-ray tube and a flat panel detector.
This facility, based on a X-ray source, a linear X-ray detector and a high precision mechanical system, has been and will be used to gather information on materials, manufacturing techniques and conservative conditions of artworks undergoing the restoration process.
Starting from high-throughput screening hits 1a and 2a, we identified a novel BCL6 corepressor interaction inhibitor 8c (cell-free enzyme-linked immunosorbent assay [ELISA] IC50 = 0.10 µM, cell-based mammalian two-hybrid [M2H] assay IC50 = 0.72 µM) by utilizing structure-based drug design (SBDD) based on an X-ray crystal structure of 1a bound to BCL6.
We have developed a transmission technique based on an X-ray tube instead of a decaying source.
A new series of N-carboxyphenylpyrrole ligands were designed using GeometryFit based on an X-ray crystal structure of gp41.
The localisation is usually determined based on an x-ray (Figs. 3, 4a, b, 5, 6 and 7a, b).
The National Trust said the new analysis by van de Wetering, based on an X-ray of the painting published in 2005 and newly found circumstantial evidence, "remarkably increased the likelihood it was by Rembrandt himself".
Homology modeling, based on an X-ray structure of rabbit P450 2C5, suggests that the locations of mutated residues are not close to the substrate binding site and therefore that structural elements outside of this site play roles in changing the catalytic activity.
In this study, we overcame these difficulties by developing a sequential Talbot-defocus multiscan method based on an X-ray microscope with synchrotron radiation.
In order to identify the critical amino acid residues involved in substrate and zinc ion stabilization in murine APN, we generated a homology model based on an X-ray crystal structure of the E. coli LAP enzyme (PDB code 3B34).
To be eligible to participate, individuals must be aged between 20 and 55 years, have a diagnosis of hip and/or knee OA (based on an X-ray or other imaging, a doctor's report or a referral letter) and be fluent in English or have a proxy to assist with completion of the study questionnaire.
