All medications were carefully recorded at the home visit, and self-reported medication adherence/nonadherence was assessed based on a validated scale (14).
An anonymous questionnaire based on a validated internationally published questionnaire was developed and validated again in own language by the primary care experts of all Hungarian medical faculties [ 13].
We considered many potential confounders: age, education, depression (based on self-reported use of antidepressant medication), vitamin E supplement use, alcohol intake, physical activity (based on a validated physical activity questionnaire), smoking status, use of cholesterol-lowering medications, and history of high blood pressure, high cholesterol, or myocardial infarction.
Numerical simulations are conducted on both the PTRs based on a validated one-dimensional computational fluid dynamics model.
In this study, the evaluation of two-phase entransy is achieved by optimizing one tube-fin heat exchanger and one microchannel heat exchanger based on a validated heat exchanger modeling tool.
The authors generated the data based on a validated, nonlinear, and one-dimensional mathematical model of distributed arterial tree [ 29].
Assessment of sleep or waking state was based on a validated computer-based sleep-scoring algorithm that used locomotor activity and filtered LFP amplitudes to assign the rat to one of four behavioural states: active wake; quiet wake; rapid eye movement (REM) sleep; or non-REM (NREM) sleep (Louis et al., 2004).
The physician claims and hospitalization files are used to define diabetes mellitus and hypertension following validated algorithms [ 11, 12], with other comorbid conditions based on a validated coding algorithm for Charlson comorbidites using ICD-9-CM and ICD-10 codes [ 23].
Both fillers achieved a clinically relevant NLF correction (one point or more improvement, based on a validated NLF severity scale).
Regarding weaknesses of our study we acknowledge that the phone-based assessment of hot flushes was not based on a validated instrument.
Previous estimates of asthma in Ontario were based on a validated asthma definition derived from population-based health services use data [ 3].
