Stidham et al 36 reported a network meta-analysis of the efficacy of three anti-TNF-α agents for the treatment of UC, based on a selection of six trials for induction response.
All relationships were confirmed based on a priori predictions, with both UC-PRO/SS scale scores demonstrating strong correlations with the Partial Mayo Score, IBDQ, worst pain, and patient and clinician global ratings of disease severity (convergent validity), and weaker correlations with measures of impact on daily life (discriminant validity).
To our knowledge, this is the first study to validate the prognostic models for UUT-UC based on a population other than Caucasian.
Characteristically, diagnosis of either CD or UC is based on a number of findings, including clinical symptoms, endoscopic features, radiologic tests, and biopsy histology.
Accordingly, up to now medical therapy of UC has been empirical rather than based on a sound understanding of disease pathology.
Based on a hospital (National Taiwan University Hospital -based analysis, we previously showed that CD as well as UC has increased in both incidence and prevalence in Taiwan [ 10- 12].
The following relations apply: where: The uncertainty from the HPLC (Uc) is a component of (ua) and was determined based on a limited number of analytical samples.
Thus, the findings reported here are based on a very small number of patients, as with other studies of IFNs in UC and CD.
Based on a random effects model, the pooled IRRs for urban compared to rural environment for UC and CD studies were 1.17 (1.32, 1.32) and 1.42 (1.60, 1.60), respectively.
