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This molecular machine can discriminate ribonucleotides based on a twofold to tenfold difference in binding constants under optimized conditions including accompanying ions in the subphase and lateral surface pressures of its Langmuir monolayer.
Furthermore, based on a twofold RNA upregulation in vehicle-treated A2780cis as well as in carboplatin-treated A2780 tumors compared to vehicle-treated A2780 tumors, GDF15, DRAM1, SULF2, P4HA2, and LMNA were selected as potential resistance-related genes (Fig. 3B).
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Genes were classified as differentially expressed based on a (moderate) twofold regulation and a false discovery rate (FDR) <1%.
In all three sets of samples, four miRNAs were significantly upregulated, based on a criterion of twofold change and P-value <0.05 (Table 1).
Dose responses were based on a 12-point inhibitor titration, using a twofold dilution series starting from 30 μM to determine the IC50 values of PERK inhibition.
Our contribution is twofold: First, based on a choice experiment we analyze how farmers evaluate actual and hypothetical features of standards.
The answer, based on a yearlong investigation by The New York Times, is twofold.
The model proposed, the Italian EUROBIS study based on an EPODE methodology, is twofold.
Differentially expressed genes were selected based on a Bayesian "volcano plot" of expression fold change greater than twofold and significance p value of <0.05, including Benjamini Hochberg false discovery correction.
Our study was designed to detect a twofold or greater difference between groups with a power of 80%, based on a two-sided test with an error α of 5%.
The first ER declares a positive response based on a threshold minimum of 5 spots per 100,000 PBMCs in the experimental wells and at least a twofold increase of spot number over background.
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