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Thus, the diagnosis of AD within the clinical routine is based on a time consuming combination of psychological testing, imaging and the analysis of three well-established biomarkers (amyloid-β42 (Aβ42), total tau and phospho-tau-181) in cerebrospinal fluid (CSF) (Blennow 2005; Blennow et al. 2010; Zetterberg et al. 2010; Tapiola et al. 2009; Dubois et al. 2007).
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Conventionally, most of the approaches mentioned are based on a time-consuming end-point analysis of the state of whole cell populations combined with advanced techniques of analysis of individual cells with the use of flow cytometry or digital microscopic techniques and image analysis.
They then argued that children who, based on a time-consuming structured interview, fully satisfied their understanding of DSM III criteria for mania, could also be identified with a relatively simple, cheap, easy-to-use symptom checklist, the Child Behavior Checklist (CBCL) [ 30].
This method is also based on less time consuming and steps than the classical methods.
The manual constitution of historic geographic data, be it based on historic maps or aerial images, is a time consuming and laborious process, however.
Currently, the design of crest-fixed profiled steel cladding is mainly based on time consuming and expensive laboratory tests due to the lack of adequate design rules.
Typically the assessment procedure for such a critical structural application, i.e. offshore platforms, has been based on highly computational time consuming processes.
Fast determination of antibiotic resistance is crucial in selecting appropriate treatment for sepsis patients, but current methods based on culture are time consuming.
Use of three video channels captures the finer details of the interaction, although the assessment of these recordings remain based on subjective and time consuming analysis [ 6].
Currently, quality assessment in our centre is done based on a complex, time-consuming evaluation of random call records [ 13].
The continuously growing variety of cars as well as increasingly shorter development periods necessitate new intelligent methods for supporting the planning and design process of production equipment, which is still based on experience and very time consuming at the moment.
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