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Sequencing-based methods are based on a substantially different strategy as compared to microarray technologies.
A number of MPS-based studies of heteroplasmy across the full mtGenome, most of them based on a substantially lower heteroplasmy detection threshold, have reported higher rates and/or different patterns of PHP than those observed in the above-referenced datasets.
This analysis was based on a substantially smaller number of cancers (3,188) than Table 3.
Our results, based on a substantially larger sample (n = 125,000), suggests a modest association between job strain and diabetes in both men and women.
Schleuter et al. [ 55] estimates that this event occurred 58 million years ago, while Blanc and Wolfe [ 54] inferred a more recent event based on a substantially different molecular clock [ 56].
Based on a substantially larger number of cases, we found a similar mean age at diagnosis as previously reported among 14 histologically confirmed breast-ACC cases diagnosed during 1952 to 1982 in the Connecticut Tumor Registry (mean age 64 years) [ 28].
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In the present analysis of the various qPCR methods, the use of the relative threshold algorithm, which is based on a sigmoidal-fit model, substantially improved the performance of both the singleplex and duplex qPCR assays, and the clinical sensitivity was increased from 40%to100%0%.
Average false positives per patient for reference readers (0.95) was not significantly lower (p-value 0.28) than CAD assisted readers' (1.27).Whereas a gold standard based on a consensus of readers may substantially bias sensitivity estimates, LCA may be a significantly more accurate and consistent means for evaluating diagnostic accuracy.
Require that new airplanes certified after 2020 reduce carbon dioxide emissions substantially based on a metric accounting for aircraft size and weight.
Unlike their U.S. counterparts, immigrants in Canada have better observed skills than natives (mainly because of Canada's immigration policy which is based on a point system), but still earn substantially less than them.
The prognostic analyses based on a long-term follow-up indicated substantially increased risk of breast cancer death for patients with high Cdc20 immunoexpression alone (HR 2.0, P=0.047) and in combination with high securin immunoexpression (HR 4.3, P<0.001).
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