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The development of this tool is based on a stepwise procedure similar to the one used successfully to generate the Molecular Lipophilicity Potential (MLP).
Based on a stepwise pH adjustment and ammonium supplement strategy, and using an in vitro mixture of cell-free extracts of the three enzymes, cyclohexylamine was produced in a titer of 14.9 mM, with a product content of up to 92.5%.
Note that linear regression models are estimated based on a stepwise regression method.
Other sampling strategies were used, such as those based on a stepwise mtSNP selection (find the best single mtSNP and then the best one to add it, and so on) but the one presented here was the most efficient in terms of maximizing the values of H and HD (data not shown).
Together, these findings call for the reclassification of mature human NK cells into distinct subsets and support a new model, in which the NK cell differentiation and functional fate are based on a stepwise decrease of NKG2A and acquisition of KIRs.
Confounders were selected based on a stepwise forward strategy.
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Only significant factors in the bilateral analysis were subsequently fitted into a multivariable analysis based on a stepwise-backward selection procedure.
Multivariate relationships based on a filtered stepwise clustering analysis were developed to facilitate the incorporation of a simulation model within a nonlinear optimization framework.
Based on a multivariate stepwise logistic model, the odds' ratios for C. pneumoniae IgG antibody seropositivity, body mass index, smoking, and consumption of pickle were 3.397 (P = 0.000), 0.858 (P = 0.014), 1.692 (P = 0.012), and 5.469 (P = 0.0000), respectively.
The inclusion of the different SNPs was based on a backwards stepwise approach.
A multivariate logistic regression model based on a forward stepwise method was used to identify the best combination to discriminate the development of overt DIC.
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