Sentence examples similar to based on a site directed from inspiring English sources

Both peptide mimetics were thus obtained as monomer and polymer forms, in agreement with a peptide-bond modification strategy, based on a site-directed design.

We further detected the function of PcNLPs protein in vitro based on the site directed mutagenesis of four amino acid residues in a conserved motif.

An approach based on the site directed mutagenesis was followed, with the preparation of two mutants showing a total loss of activity.

Based on site directed mutagenesis combined with methanethiosulfonate reactivity a core common mode of action of ATP binding at P2X receptors has been proposed consisting of lysine residues adjacent to the transmembrane domains coordinating phosphate binding, an NFR motif binding the adenine/ribose moiety and an FT motif also involved in agonist action [ 21].

In order to explore this unusual Y-type oxyanion hole, and to improve LipR performance, two modification strategies based on site directed or saturation mutagenesis were addressed.

A mechanism based on active-site directed inactivation of the enzyme by disulfide bond formation between the active site cysteine thiol and the sulfur atom of the heterocycle is proposed.

Based on a directed evolution approach, here we provide the first quantitative characterization of the binding preference of the DYNLL binding site.

It is based on a Cosserat or directed rod theory.

Terpene synthase mutants were constructed by site-directed mutagenesis based on the QuikChange site-directed mutagenesis kit (Agilent) using designed mutagenesis primers (Table S2).

A number of studies based on deletion and site-directed mutagenesis demonstrated that the central helices in these BCL-2 family proteins are required for pore formation and for both cytoprotection and apoptosis induction [29], [30], [31], [32], [33].

The assay was based on a two-site ELISA sandwich format using two antibodies directed against different epitopes of MMP-9.