In May 2012 we implemented an accelerated work-up and treatment program with a seamless patient path based on a formal collaboration between the neurologically staffed DHC (TH, SM, RHJ and LB), the Department of Radiology (FW) and the Department of Neurosurgery PRR).
Development of TREC is based on a modified yeast system where generation of seamless deletions [ 22] and point mutations (unpublished data) in the mycoplasma genome is now made possible by using the yeast DNA repair machinery.
The indacaterol doses administered in this study (150 μg, 300 μg, and 600 μg) were selected based on a dose finding study which used an adaptive seamless study design [ 16], and which identified the 150 and 300 μg doses for further development.
Over the last decade, there has been a paradigm shift regarding how biomedical data is used for biomedical research, moving from a single database based approach towards an integrative one based on the seamless access and analysis of data from multiple heterogeneous sources.
Our strategy was based on a two-step protocol that combines HDR triggered by TALENs with seamless removal of the selection cassette by an improved PB system [ePB terminal repeats used in combination with the hyperactive int transposase].
At the Doris Duke Studio Theater, Annie-B Parson, who works magical oddities into a seamless blend of theater and dance, will present "A Simple Heart," based on a Flaubert short story.
There is a seamless transition between primary, secondary, and tertiary maternity services in New Zealand, based on a comprehensive guideline for referral to obstetric and associated medical specialist care [ 25].
The concept is based on a series of distinct components supported by a common semantic knowledge base, enabling the seamless collaboration of partners of multiple disciplines for the realization of product-services.
As with most historical accounts based on a single theory of causation, the facts here don't always square perfectly with the seamless web that Healy has tried to weave.
Integrated care is an organizational coordination process that seeks to achieve seamless and continuous care that is tailored to the patient's needs and based on a holistic view of the patient [ 3].
