Sentence examples for based on a scaffold from inspiring English sources

These extensions will allow users to simultaneously dock multiple ligands and perform fragment-based design based on a scaffold and a library of small chemical fragments.

They are engineered binding proteins based on a scaffold of the three-α-helix bundle Z-domain (Friedman and Ståhl [2009]; Nilsson and Tolmachev [2007]; Nygren [2008]).

We have developed a series of orally efficacious IRAK4 inhibitors, based on a scaffold hopping strategy and using rational structure based design.

For example, in a recent study 64Cu-labeled tumor-targeting peptides based on a scaffold from staphylococcal protein A (affibodies) had kidney and liver uptake values ranging from 40 240%ID/g and 5 12%ID/g, respectively, during measurements taken over 20 h post injection [41].

Ferrigno's group developed peptide aptamers based on a scaffold constructed by mutations of Stefin A protein (a cysteine protease inhibitor).

Therefore, this study highlights a novel, non-reboxetine-based NET PET tracer based on a benzothiadiazole scaffold: [11C]Me@HAPTHI ((S -1- 3-hydroxy-4- [11C]methylamino butyl -3-phenyl-1,3-dihydrobenzo[c][1, 2, 5]thiadiazole 2,2-dioxide) (Fig. 1).

Figure 3 A selection of compounds (b) based on a common scaffold (a).

Result structures of a COLIBREE design run are based on a fixed scaffold and variable linkers and side-chains.

A new family of protein farnesyltransferase inhibitors, based on a phenothiazine scaffold, was designed and synthesized.

Novel photoinitiators based on a phenazine scaffold are proposed for the ring opening polymerization of epoxy monomers as well as the free radical polymerization of (meth)acrylates.

While no interaction was detected for nitrogen N1, all active compounds of MUV548 that are based on a pyrrolopyrimidine scaffold also contain this nitrogen.