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For cytostatic agents or when the response assessment is difficult, adaptations to phase II designs may allow a better assessment of therapeutic activity: first by using the progression-free survival rate (PFSR) as primary end-point instead of the response rate, and second by considering progression-free survival (PFS) risk groups based on a prognostic index (PI).
Identification of defined patient groups based on a prognostic index may improve the prediction of survival and selection of therapy.
We envision to contribute to a matching policy based on a prognostic risk score for immunisation in general transfused patients.
In recent years, a definition based on a prognostic risk score has been shown to have better predictive validity for pain outcomes than pain duration alone 45.
This recommendation is based on a prognostic analysis of 8088 patients with SCLC in the IASLC database with adequate data to determine clinical (c) or pathologic (p) TNM stage.
The predicted survival was based on a prognostic model that used cases over the whole period to avoid the survival effect of changes in treatment between the different periods.
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Because tumorsphere formation was necessary for inclusion in the present protocol, patients were actually included based on a negative prognostic indicator.
In conclusion, the method based on a continuous prognostic index was apparently able to refine the classification of survival times in the present renal cell carcinoma patients.
Importantly, patients who share similar prognosis (at least from a statistical, population perspective) based on a similar prognostic score might not necessarily be considered as belonging to a specific phenotype.
Concurrent with this, the MSKCC criteria were modified based on a new prognostic model in which time to treatment with IFN replaced the presence or absence of prior nephrectomy.
Prediction of outcome and treatment planning should be based on a panel of prognostic factors, rather than on a single prognostic factor since no such has proven superior to predict MCT prognosis alone [ 9, 10].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com