Sentence examples for based on a polygenic from inspiring English sources

The report is based on a polygenic risk score, a genetic calculation that weighs a person's odds of developing a medical condition.

Robust methodology has been developed to account for genetic background, based on a polygenic model and which is implemented in the GRAMMAR-CG approach used in the analysis presented here.

Thus, genomic pre-selection (GPS) leads to biased EBV and reduced accuracy in national genetic evaluations based on a polygenic model [ 10].

Today, we know that obesity and IR are based on a polygenic background with many single nucleotide polymorphisms with small effect sizes.

Monogenic mutations such as those described for LEP, LEPR, POMC, and MC4R cause only a minority of obesity cases whereas in most individuals obesity is based on a polygenic predisposition amplified by an obesogenic Western lifestyle [ 4].

The environmental correlation (Rho E) of BMI with the "unhealthy" factor was found to be significant (Rho E = 0.16, P = 0.01).> -wrap-foot> Heritabilityty, SE standard error of heritability of sibship estimate, S sibship effect, NA not applicable aHeritability estimates were based on a polygenic model including age and gender as covariates.

The aim of this study was to model the efficiency of a personalised screening strategy based on a combination of age and polygenic risk-profile compared with a strategy based on age alone in prostate and breast cancer.

Population stratification was adjusted by including a random polygenic effect based on a matrix of genotypic relationships.

Estimates of the autosomal heritabilities for effects on androstenone for LRT poly are summarised in Table 3.> -wrap-foot> Testrategyrategy was to compare fitting a random polygenic effect (based on a GRM estimated using all genotyped SNPs across the genome) plus a random effect for variance attributed to SNPs from a single autosome with a reduced model fitting only the random polygenic effect.

Therefore, our polygenic analysis was based on a subset of 3285 unrelated subjects comprising of 1188 patients and 2097 controls.

Heritability was estimated based on a kinship matrix calculated from the 60 K SNP genotype data and using the polygenic function.