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The FDA approved lapatinib for patients with HER2+ MBC who had received prior anthracycline and taxane-based chemotherapy and were progressing on trastuzumab-based therapy based on a phase III trial, comparing lapatinib/capecitabine combination with capecitabine alone.
Note that the LCST transitions described in the literature, including the ones described above, are based on a phase change in solution, where the soluble molecules fall out of solution in response to an increase in temperature.
A relative potency of one vial of Fab to two vials of F ab' 2 was assigned based on a Phase 2 clinical trial and mouse ED50 comparisons.
Simulation data were generated from a model developed based on a Phase I study.
Responsiveness of thin polymer films is based on a phase segregation mechanism.
Homogeneous liquid liquid extraction method was studied based on a phase separation phenomenon in a ternary solvent system.
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The extended model is based on a phase-field formulation and is fourth-order in space.
We propose a model based on a phase-field approach to study grain-boundary segregation and solute drag.
The brittle fracture model is based on a phase-field approach for cracks in elasticity and pressurized elastic solids.
Based on a phase-plane analysis, we manage to deduce the global bifurcation properties and to solve the boundary-value problem analytically.
In this work, we integrate a morphology evolution framework (based on a phase-field model) with a heuristic optimization scheme to systematically identify promising processing conditions.
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