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A strong synthetic painkiller based on a peptide found in one species, Conus magus, is already in the late stages of clinical trials.
Based on a peptide screen, three CaM binding sites have been reported, one in the N-terminus (BD-N) and two in the C-terminus (BD-C1 and BD-C1).
The antimicrobial peptide sequence used for immobilization in this research was based on a peptide previously synthesized by Hilpert et al., the Tet-124 sequence KLWWMIRRW, which shows a minimum inhibitory concentration (MIC) of 8 μg/ml against Pseudomonas aeruginosa strain H1001.
This molecule is not based on a peptide and has no obvious structural similarity to a protein substrate.
The structure of ritonavir, a protease inhibitor based on a peptide and containing three peptide bonds, is shown on the right.
The objective of this dose/adjuvant-finding study was to evaluate the safety, reactogenicity and immunogenicity of a vaccine candidate based on a peptide spanning the C-terminal region of Plasmodium falciparum circumsporozoite protein (PfCS102) in malaria naive adults.
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Herein, we highlight the technical feasibility of generating a functional mini thymus with a novel hydrogel system, based on a peptide-based self-assembly platform that can induce the formation of 3-D thymic epithelial cell (TEC) clusters.
The design of these peptides was based on a lead peptide with an IC50 of 3×10−7 M, previously identified by us [M. Balass et al., Proc. Natl. Acad. Sci. USA 94 19977) 6054] using a phage-display peptide library.
Twenty proteins (51%) were identified based on two or more peptide matches; 19 proteins (49%) were identified based on a single peptide match.
Of these, eight proteins were identified based on two or more unique peptides (Table 2) and in 22 the identification was based on a single peptide (Table 3).
Self-assembling organic nanotubes based on a cyclic peptide architecture.
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