Sentence examples for based on a mutation from inspiring English sources

ATP6AP2 has been associated with cognitive disorders based on a mutation identified in one family with seven affected males presenting with mild-to-moderate intellectual disabilities, delayed motor milestones and speech acquisition, and generalised tonic-clonic seizures (1, 2).

To gain mechanistic insights, we developed a novel mouse model based on a mutation in human optineurin associated with hereditary, low-pressure POAG.

Champagne is a dominant trait, based on a mutation in the SLC36A1 gene.

For a bacterial genome consisting of about a thousand genes of comparable size, this corresponds roughly to a few hundred million years of evolution (based on a mutation rate of 0.003 per genome per replication [24] and a generation time of 0.001 year [25]).

Based on a mutation rate of 1.3%/bp/million years (combined cytochrome b (1.38% MY) [37] and NADH5 (1.22% MY) [38], 601 bp of sequence (NADH5 and cytochrome b) and τ values between 2.605 and 4.24 (Table 6), our estimates of the range expansion for jungle cat in India dates to the mid Pleistocene (166,709 to 271,342 years ago).

For example, inherited susceptibility to aminoglycoside ototoxicity is based on a mutation in mitochondrial DNA (i.e., 12S rRNA) [ 11].

In contrast, in a genetic cancer syndrome which is not based on a mutator mutation, familial adenomatous polyposis (FAP), we see an increase in the number of polyps at least equivalent to the increase in the number of cancers.

The model is based on a point mutation corresponding to the p53 mutated hotspot p53.R273H in the human Li Fraumeni cancer syndrome.

It should be kept in mind that impact of mutations on Gleevec resistance reported so far is based on a single mutation for each patient.

Using a mutation operator, a few genes of a candidate chromosome are randomly selected to change their values based on a predetermined mutation probability of pm.

Bi et al. [49] suggested an adaptive differential EA based on a new mutation operator, which employs Pareto-optimal solutions to guide the evolution of a population and provides more information for producing new individuals directionally.