Sentence examples for based on a murine from inspiring English sources
Based on a murine airway infection model, inactivation of mutS renders P. aeruginosa less virulent [28], [43].
This model is based on a murine experimental model as this is the "in vivo" model for which most information is available.
Reports based on a murine model showed that no mice survived when the whole CTLA-4 gene was knocked out [6].
Based on a murine spleen injection-liver metastasis protocol, the alpha3beta1 integrin subtype was identified to predominantly facilitate the metastatic activity of colon cancer cells [ 17].
Previous publications have described a prototype based on an amphotropic murine leukemia virus (MLV), encoding yeast cytosine deaminase (CD) that converts the prodrug 5-fluorocytosine (5-FC) to the potent anticancer drug, 5-fluorouracil (5-FU) in an infected tumor.
The dual promoter small interfering RNA (siRNA) expression vector pMEHMpuro was constructed based on a self-inactivating murine stem cell virus plasmid, namely pMSCVpuro.
Specifically, an estimate based on a wide range of murine studies indicates that a given T cell clone can react with approximately 10 different peptides.
In the case of RA, AID lncRNAs were more abundant in the T-cell compartment (memory T, naive CD8+ T, ThP, Th0, Th2 cells), which agrees with a study based on a statistical approach to murine immune cells demonstrating enrichment of protein-coding genes in CD4+ memory T cells [ 56].
For a proof of concept, we developed a construct consisting of recombinant bifunctional single-chain variable fragment (scFv) based on a monoclonal antibody against Friend murine leukemia virus (F-MuLV) envelope protein gp70, which was coupled to specific binding domains (short consensus repeats 19-20; SCR1920) of FH.
The inhibitory effects of the test compounds on NO production were evaluated based on a detection model with LPS-activated murine macrophage RAW264.7 cells, which was performed as described previously [15].
To evaluate better the possible discrepancy between chimeric antibody concentration measured by UV absorbance and the true corresponding functional concentration, a comparative experiment was designed based on a sandwich enzyme immunoassay taking the murine wild-type antibody as reference (see methods).
