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Through the use of computational modeling, a series of pyrimidinetrione-based inhibitors of MMP-13 was designed based on a lead inhibitor identified through file screening.
The designed single infusion syringe pump is based on a lead screw mechanism.
Analogues were designed based on a lead compound that was previously determined to have selective activity as a GPR35 antagonist.
The mustard tint on the robe of a majolica (glazed terracotta) angel by the Renaissance Della Robbia workshop is based on a lead and antimony colourant — a family of yellows that sometimes also incorporates tin.
The design of these peptides was based on a lead peptide with an IC50 of 3×10−7 M, previously identified by us [M. Balass et al., Proc. Natl. Acad. Sci. USA 94 19977) 6054] using a phage-display peptide library.
Staying on the same topic, we'll also point out that you should offer different kinds of content based on a lead's position in the buying cycle.
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The faulty model, known as the Sprint Fidelis lead, was a follow-up product based on a Medtronic lead that was originally approved a decade earlier.
Those numbers, he said, are calculated based on a blood lead level (BLL) of 10 micrograms per deciliter (mg/dl).
Herein we report the design and synthesis of a series of simple phenol amide ERRγ agonists based on a hydrazone lead molecule.
Based on a previous lead compound and rational drug design, acyl derivatives of α-aminonaphthylmethylphosphonic acid were synthesised and tested as PAP inhibitors.
Anyone saying Hillary is a sure thing based on a big lead in polling, her fundraising advantages, and her status as favorite doesn't know his presidential election history very well.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com