Sentence examples for based on a genome from inspiring English sources
The assembly procedure may include already available reference sequences (guided approaches), as in the case of transcript assemblies based on a genome reference, or they are based on reference-free methodologies (de novo) [77].
Together the libraries represent 9.7× genome coverage based on a genome size of 272 Mb [7], [17].
We addressed this question by developing statistical models based on a genome wide profiling of normal tissue adjacent the tumour and identifying aspects that are predictive of cancer features.
This challenge is critically important [9], for a single, circular nucleotide sequence of the complete chromosome is a necessary prerequisite for confident and complete research based on a genome.
Based on a genome size of ~ 430 Mb, the recombination rate estimate is 4.76 cM/Mb.
However, a transcriptome may underestimate gene diversity, as compared to studies based on a genome.
We compared the positions of GWAS regions to 182 regions (163 autosomal, 19 X-linked) with evidence for epistasis based on a genome-wide analysis of genomic clines in a transect across the house mouse hybrid zone in Bavaria (Janousek et al., 2012), the same region where the progenitors of the mapping population were collected.
In our current study, we identified 226 potential candidate vaccine genes against L. interrogans using in silico analysis, comparative genomic hybridization (CGH) and transcriptional analysis, based on a genome-wide DNA microarray comprising 3528 open reading frames (ORFs) derived from the original annotation of L. interrogans strain #56601.
"Our model uniquely accounts for the chronology of a patient's disease and is based on a genome-driven classification scheme that can inform personalized therapeutic approaches," Curtis said.
We therefore explored a new approach based on a genome-wide bioinformatics strategy that revealed novel cardiac-specific cis-acting regulatory modules (CS-CRMs).
After leaving for the university job in China in 2012, Dr. He sought Dr. Quake's help with starting a company based on a genome-sequencing technique Dr. Quake had invented.
