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We undertook a systematic performance evaluation of 14 candidate blood-based markers for EOC selected based on a gene expression data and published literature.
A TA 7TAA reportedly has only one-third of the transcriptional activity of wild type, based on a gene expression study with the regulatory region from c.-546 to c.-4 [ 11].
A more general example of such a structure (than the present pathway-based hierarchy) involves, for a given gene set, a tree structure based on a gene ontology (GO) [ 12] tree, which will be studied in future work.
The study, based on a gene called Myc, could lead to new ways of treating cancer.
This is a family tree drawn up by Dr. Woese and based on a gene used by all living cells to specify ribosomal RNA, or ribonucleic acid, a component of the machinery that translates genetic information into working parts.
The potential treatments and tests are based on a gene identified by the company.
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The independent t test for each experiment was able to detect genes that were significantly expressed even with low expression ratios because unknown error variance components were estimated based on a gene-specific variance for each gene.
In order to cope with the increasingly appreciated complexity of living organism, implicitly, biologists have adopted a reductive approach, mainly based on a gene-centric paradigm, where causative processes are modelled according to a simplified, linear dynamics.
Despite tremendous research and clinical efforts, the molecular causes remain unknown for nearly half of the patients, due to genetic heterogeneity and conventional molecular diagnosis based on a gene-by-gene approach.
The final GS network (iRP911) contained 1139 unique reactions and 977 metabolites, and was based on a gene-to-protein-to-reaction (GPR) association network that included 911 genes encoding 761 proteins (Table 2, Additional file 2, 3).
We chose target genes based on a target gene that was recognized by at least two algorithms.
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