In this study, a small series of phosphonic acids were designed based on a new crystallographic structure of LMW-PTP complexed with benzylsulfonic acid, determined at 2.1 Å.
This relationship has been used for cold-rolled crystals of cube and Goss orientations to estimate the location-dependent shear strain based on a local crystallographic measurement by electron back-scattering patterns (EBSPs).
The present model is based on a combination of crystallographic and experimental data and points toward three key amino acid positions: W116, F296, and Y375.
However, the predictions are still based on a restricted number of crystallographic data sets primarily due to the lack of a robust and versatile expression system for soluble TCRs necessary for obtaining sufficient amounts of protein.
Thus, the only validation of the predicted SDRs utilized information available from homologous GPCRs: In a homology model based on a high-resolution X-ray crystallographic structure of rhodopsin [40], the 22 putative SDRs occupy the region corresponding to the retinal binding site.
We designed a series of pyrazole-based carboxylic acids as candidate ligands of heart fatty acid binding protein (H-FABP, or FABP3), based on a comparison of the X-ray crystallographic structures of adipocyte fatty acid binding protein (FABP4 selective inhibitor (BMS309403) complex and FABP3 elaidic acid complex.
In addition, a novel mode of CaM target recognition has been recognized based on our high-resolution crystallographic data, being based on a '1-11' motif, not predictable from the sequence of the CnA-CBD.
Based on an analytical deduction, the crystallographic and lattice point correlations between the initial hcp and final fco structures are obtained, respectively, and the deduced correlations may also be of relevance for another two phase transformations: the hexagonal close-packed to body-centered tetragonal, and hexagonal close-packed to face-centered cubic martensitic phase transformations.
Based on this crystallographic view, a seeding mechanism for Eph-ephrin signaling platform formation was proposed18,19.
