In this report, we use the GL261-cell based mouse model of malignant glioma, as well as human glioma (grade 2 4), to investigate the hypothesis that Th17 cells infiltrate brain tumors.
These projections lying within the hippocampal layer stratum lucidum (s.l., Figure 1a) are specifically prone to pathological Tau hyperphosphorylation and aggregation in a FTDP-17 based mouse model overexpressing the repeat domain of Tau with the mutation ΔK280 (TauRDΔ) in the forebrain [ 7, 8].
Indeed, a vast number studies have demonstrated deficits in adult neurogenesis in amyloid-based mouse models of AD [6] [10], [31], [34], although a conflicting study has also been reported [35].
Further, these studies support the concept that MYC-based mouse models of prostate cancer are useful "reagent mice" for studying the genetic, epigenetic, and microenvironmental changes that cooperate with MYC and lead to advanced and metastatic disease.
Because MPTP models recapitulate dopaminergic cell loss, they are among the most frequently used toxin-based mouse models of Parkinson's disease in which cellular protective strategies have been examined.
STACs could also be beneficial in neurodegeneration (Zhao et al., 2013) based on mouse models of Alzheimer's or Parkinson's disease and multiple sclerosis (Graff et al., 2013; Hubbard & Sinclair, 2014).
"There's been a lot of handwringing over the failures of drug trials based on findings from mouse models of Alzheimer's," Dr. Small said in a press release.
sciuri W620 seem to be the most promising, based on experimental studies in mouse models of allergic respiratory diseases.
Both of these hypotheses appear to be incorrect based on information gleaned from mouse models of Down syndrome and also from later genomic and phenotypic correlations of individuals with Down syndrome.
