Similarly, when designing studies or developing genetically based mouse models of specific conditions, background genotypes and phenotypes may provide substantial advantage or disadvantage to achieving specific aims.
Such partial losses of DA neurons that we see in the Substantia nigra of the A53T transgenic model, have also been previously described in genetic, and toxin based mouse models of PD [33], [34].
These projections lying within the hippocampal layer stratum lucidum (s.l., Figure 1a) are specifically prone to pathological Tau hyperphosphorylation and aggregation in a FTDP-17 based mouse model overexpressing the repeat domain of Tau with the mutation ΔK280 (TauRDΔ) in the forebrain [ 7, 8].
Rath P, Nardiello C, Solaligue DE et al. Caffeine administration modulates TGF-beta signaling but does not attenuate blunted alveolarization in a hyperoxia-based mouse model of bronchopulmonary dysplasia.
In a recent study using an ApoE−/−-based mouse model of atherosclerosis, inhibition of Shh using specific antibodies resulted in a pro-atherosclerotic phenotype secondary to enhanced lipid uptake in macrophages [ 3].
Relevance to the human disease was bolstered by demonstrating the important role for PARP in a HDM-based mouse model of the disease that more closely reflects human asthma.
In an endotoxin-based mouse model of inflammation, administration of aspirin or indomethacin nearly abolished both PGE2 and PGD2 synthesis, whereas PGD2 levels rose during the natural resolution of inflammation in untreated animals [ 33].
The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP -based MPTP -based of Parkinson's disease has been studied for >20 years and is therefore well characterized in mouseand modelys (Langstof et al., 1983; Cannon and Greenamyre, 2010).
STACs could also be beneficial in neurodegeneration (Zhao et al., 2013) based on mouse models of Alzheimer's or Parkinson's disease and multiple sclerosis (Graff et al., 2013; Hubbard & Sinclair, 2014).
In a previous study by Aguilar and colleagues [ 12] based on a mouse model of progressive pulmonary tuberculosis, M. bovis strain 04 534 showed an attenuated phenotype, whereas strain 04 303 was the most virulent in mice.
