Integration of TKTD models with spatially explicit models for populations, such as individual or agent based models, may be one possible solution if the assessment is carried out at the population level.
Thus, network based modeling may be a useful adjunct for the design of double knockout experiments or combination inhibition experiments to permit a more efficient search for synthetic lethals.
For example, the alarm function of a rate-based model may be simply calculated as a sum of the rates over a magnitude range (Kossobokov 2006).
While some form of lagged weather- and or climate-based model may be indispensable [35], the simpler MHW alternative may forecast fully- or partially-stable disease TS, e.g., meso-endemic malaria transmission in the district of Niono.
In the simple example considered, a rule-based model may be unnecessary, but the size of an ODE model tends to increase exponentially as components are added if the model incorporates site-specific details [ 7, 8, 10] and eventually a rule-based approach would be required.
Beyond Atlanta, where many large companies are based, this model may be less replicable in other, more rural parts of the state.
However, the PM3 semiempirical model appears to provide an even better description for these systems and, given sufficient computer resources, direct dynamics methods based on this model may be preferred.
Safety behavior promotion strategies designed based on the integrative model may be well suited for both large and small companies.
At the same time, however, with the same probability, the capacity estimation based on the deterministic model may be an overestimation of the actual capacity, with the result that, for a given traffic demand, the oversaturated conditions at entries are not highlighted.
