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This OP-based model is refined by extracting new model coefficients from 3D DEM simulations of homogeneous shear flow.

After a learning interval, the model is refined based on the measured data.

Thus, the music model is refined iteratively.

In step 3, the permeability model is refined.

More substantial questions arise when this phenomenological model is refined into a more detailed model.

In later rounds of refinement, the model was refined with amplitude based twin refinement.

The logic model was refined based on the focus group and interview data.

The covariate model was refined based on point estimates, CIs, and diagnostic plots rather than on the OFV.

31 The pharmacophore model was refined further based on the binding pocket of the dopamine D1 receptor (drd1) structure model.

The model was refined conservatively, and based on the behavior of Rfree and other indicators we decided that a combination of TLS with two grouped B-factors for each residue represented an optimal strategy.

The whole HFPNe model was refined by CL and MN.