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This indicates that most of the WSSV genes are either 1) lineage-specific, 2) have high evolutionary rates and cannot be detected with the homology-based methods we utilized, or 3) were not recovered due to the selective loss of genes in the fossilized viral genomes.

For every data set, the entropy based methods are utilized for discretizing all the attributes, which has been done by Rapid miner 5.1 [41].

Further, computational based methods were utilized to predict the effect of identified mutation on the structure and function of HPRT enzyme.

In the literature, various methods such as Gaussian filtering, Average filtering and several wavelet transformation based methods have been utilized in spectra de-noising [ 9].

Traveling wave based methods utilize the principle of the electromechanical wave propagation [17] to locate the oscillation source.

On the other hand, BLAST based methods do not utilize the structural information and can not distinguish the true alignment from biological similar nodes.

The suicide mini-CTX2 plasmid based method was utilized for site-specific integration of the second copy of fabG.

This new body frame based method utilizes the concept of Euleraxis and angles to generate the smallest error angles from a body frame perspective, without coordinate transformations.

For these two reasons, the gene set based method cannot fully utilize the TF binding information derived from ChIP-seq data and is ultimately less robust than REACTIN, as has been shown by our results (Additional file 5: Table S5 and Additional file 7: Table S7).

In contrast to the conventional voxel based methods, the proposed algorithm utilizes more accurate photo-consistency and reconstructs the 3D shape up to sub-voxel accuracy.

Several generalized likelihood ratio test- (GLRT-) based methods are proposed, which utilize secondary (training) data, that is, data vectors sharing the same spectral properties, to form an estimate of the disturbance covariance.

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