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All regression models conducted in this study will be run using likelihood based methods to account for missing data.
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Shah et al. [ 17] have proposed a similar HMM based clustering method to account for spatial correlation, but is fundamentally different from our clustering method in a number of ways First, the models are different.
The time-dependent covariate of infection was correctly modelled by a state based method; failure to account for timing of infection is an important source of bias.
Methods to account for bias.
More advanced model based methods that account for tertiary (and subsequent) cases and community introduction would be warranted with more complete data sources.
Traditional case-mix adjustments via multivariate regression based methods cannot completely account for the selection bias.
Unlike distance based methods, they can account for any conceivable evolutionary rate, and any number of differences per site.
Afterward, we used the Stata (Stata, College Station, TX) program "metan" (32) to generate summary and pooled odds ratios (ORs) using an inverse variance-weighted random effects analysis based on the DerSimonian and Laird method to account for within- and between-study variation (33).
Literature suggests that a statistical based method can account for variability and a large number of influencing factors, and could be a promising alternative.
Traditionally simple schedule based methods have been used to account for the effects of occupants.
Although our steady-state based method does not account for capacity limitations in various enzymes, and thus the beneficial, deleterious or regulatory role of metabolite concentrations, the model's adherence to conservation of mass balance and network connectivity imposes pseudo-metabolic regulation.
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