Sentence examples for based methods is that from inspiring English sources
The key difference between sequence-based and gene expression based methods is that the latter provides quantitative information, not just qualitative sequence identities.
The defect of least square based methods is that they create a delay in estimation process but Kalman filter based methods provide instantaneous estimation.
The main limitation of composition based methods is that the length of fragments may significantly influence their performance.
Further, a known limitation of bisulfite sequencing based methods is that the protocol is unable to distinguish difference between 5-methylcytosine and 5-hydroxymethylcytosine.
A major limitation of this method, as with all 2D SDS-PAGE based methods, is that it cannot reliably visualize or produce analytical quantities of low abundance proteins that are present in less than 1000 copies per cell.
It has often been considered that one of the advantages of ML over parsimony based methods is that it allows for the use of different models of evolution depending on the dataset being examined.
A possible limitation of IDM-based methods is that full recovery of the signal is not obtained, and a residual PVE of about 10 15% was observed.
One of the advantages over the landmark-based methods is that SHR is able to register low-resolution face images with an interocular distance as low as 25 pixels.
However, a limitation of IRT-based methods is that missing data (e.g., resulting from CAT administration) can reduce accuracy in parameter estimates and in DIF detection [ 19, 20].
An advantage of the sequencing-based approach over hybridization-based methods is that changes in expression profile of individual members within a miRNA family can be determined.
