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NAAT based diagnosis has been observed to be significantly more sensitive than conventional methods such as culture and antigen based methods for diagnosis of C. trachomatis in clinical specimens.
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Fast diagnosis is important in CUP and new methods include immunohistochemical and gene expression based methods for tissue-of-origin identification [ 23, 26, 27].
In this study, we did a meta-analysis to summarize and compare the accuracy (sensitivity and specificity) of the GeneXpert (a molecular based assay), the MODS (a rapid culture method) and the WHO 2007 algorithm (an algorithm based method) for the diagnosis of SN-PTB.
PCR-based methods for diagnosis of WD have been developed.
This feature is an arduous task, given the increasing reliance on non culture-based methods for diagnon culture-basedn with B. pertussis.
In the absence of commercial systems largely validated in multicenter studies, "in-house" PCR based methods remain used worldwide for the diagnosis of candidemia.
and some microarray based methods have shown significantly improved consistency [ 17– 21] and predictive value for aneuploidy diagnosis [ 22, 23].
The MSPCA based method essentially captures the fault-symptom correlation, whereas KECA can be an effective method for process fault diagnosis.
For suitable diagnosis and treatment, rapid and accurate identification of etiologic agents in clinical samples using reliable molecular based method is required.
Moreover, several studies have verified the usefulness of nucleic acid amplification based methods for diagnosis of Mycobacterium tuberculosis infections in <24 hours (2– 4).
However, based on the research dedicated to this field, there is no highly sensitive network-based method for carcinogenesis characterization and diagnosis from the systems perspective.
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