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New mechanistically based methods could be established from all these approaches, which, once validated, could enter the regulatory procedure.
Similarly, if active compounds are known, ligand based methods could be used to select a screening library which includes additional compounds similar to them.
The Sreekumar study together with other recent studies [10], [11], [12], [13] truly indicate that mass spectrometry based methods could be used to characterize metabolomic changes during cancer progression and further to identify possible diagnostic and prognostic biomarkers or biomarker patterns as well as increase our knowledge about disease progression.
At regional sites non-culture based methods could be applied.
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The thermal instability of PHB purified by alkalis based method could be due to PHB hydrolysis.
We also showed that this literature based method could be used to compare the cohesion of gene sets obtained from microarray experiments [ 40].
In the setting of a cluster of infections with a specific organism for which it is suspected that the environment may play a significant role in patient acquisition and transmission, culture- or polymerase chain reaction-based methods could be implemented to assess effectiveness of PDC to limit further nosocomial transmission of the specific organism [ 33, 34].
As explained in the Introduction, we focused on the DDM because it is the most widely used height and weight-based method, and we reasoned that, since the other height and weight-based methods only differ from the DDM in the coefficients and exponents employed, if the DDM was found to be inaccurate, the other height and weight-based methods could be assumed to be inaccurate too.
As such, we reasoned that, if we found the DDM to be inaccurate, the other weight and height-based methods could be assumed to be inaccurate too.
Furthermore, inquiry-based methods could be used to teach scientific problem-solving.
Of course, other, plot-based, methods could be used to estimate the population size, perhaps with greater precision.
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