Motion estimation based method cannot be useful for the second type of continuous scratch.
Even though the Doppler information is present in the histogram of the Doppler OCT image, histogram-based methods cannot be readily applied, as the contribution of the flow in the histogram is so small that it does not lead to distinct modes in the histogram (see Fig. 1 ).
Thus, standard convex optimization tools (e.g., subgradient-based methods) cannot be directly applied to solve master problem (7).
If DNA is not present, then these DNA-based methods cannot be used for subtype identification.
The conventional samples, analysed by PCR-based methods, cannot be easily used for testing new variants.
Due to the structures of most proteins are not available, the structure-based methods cannot be generally used.
However, standard tree-based methods cannot be applied here since the output μ i (t ) is a latent variable.
Therefore, side effect-based methods cannot be applied to new drug candidate compounds (e.g., newly synthesized compounds) that are yet to have their side effects profiled.
Since the goal of this study is not only to assign specific functions to genes but to also identify functional relationships between whole gene clusters, such score-based methods cannot be used.
However, as discussed by Naveed et al., template-based methods cannot be applied to novel folds, such as transmembrane β-barrels with an odd number of β-strands (Naveed et al., 2012).
This is partially due to the fact that these coding sequence based methods cannot distinguish retrotransposed genes from the original copies unless retrotransposed genes are sufficiently diverse.
