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Model based methods can give an important contribution to cope with the drastically increased complexity in ECU calibration.
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Based on how a given ligand is represented, these methods can be divided as 2D fingerprint, molecular shape, pharmacophore, and bioactivity spectrum-based, etc. Chemically similar drugs often bind biologically relevant protein targets.
In general, sequence comparison-based methods can give more improved predictions than free-energy-based predictions if the homologous sequences are available.
Alignment based methods can be further divided into sequence alignment based and structural alignment based methods.
Furthermore, given the need for a short time window, no frequency based method can be applied on account of loss of resolution.
Such methods can give thus for regional scientist, economist and politicians an extra confidence in their decisions and can help in solving endless disputes that are based on subjective interpretations.
In general, all three methods can give comparable results.
Taking this integration of direct marketing methods further by combining them with other off-line marketing methods can give marketers the greatest power at the lowest cost.
Both methods can give interesting and potentially therapeutically useful results.
Therefore, the proposed method can give a higher accuracy.
We found that the oligonucleotide based methods gave different results compared to that of the proteome based methods.
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