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The latter volume based method can describe inhomogeneous and non-linear media and has been proven to be unconditionally stable.
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The former surface based method can accurately describe outwardly radiating fields from piecewise uniform objects and efficiently deals with large domains filled with homogeneous media.
(4) Compared with Menger sponge model, the fractal dimension based on thermodynamic method can describe the pore size distribution in the whole test range more comprehensively, and it is more suitable for solving the fractal dimension of concrete in this kind of environments.
Alignment based methods can be further divided into sequence alignment based and structural alignment based methods.
A two-parameter model based on a Langmuir Hinshelwood rate expression, using activity coefficients from the UNIFAC method, can describe the experimental kinetic results.
The BASE method can be described as follows; given a TF with binding affinity b i and an expression differentiation profile e i (i = 1,2,...,N and N is the number of genes), BASE calculates the correlation between these two profiles using a Kolmogorov-Smirnov test like method.
The in vitro transcription (IVT) based method described there can be used in two cycles of cDNA synthesis and IVT and it is currently broadly used for expression profiling from nanograms of RNA [8], the equivalent of 1,000 or more cells.
As shown in Figure 1C, the common hypothesis underlying these gene expression based methods is that every biological state can be described through a proper gene signature, which can be defined as a set of genes combined with a specific pattern of expression.
Based on the time-temperature superposition principle, this method can be described as a short-term creep experiment during which the temperature is elevated stepwise.
This can be overcome by using spectral based methods.
This can be avoided by using LC-MS/MS based methods [ 16].
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